Application Process and Requirements for Investigator-Sponsored Research

Applications submitted to the AMS Investigator-Sponsored Research program are completed through the online Investigator-Sponsored Research Submission Portal. The application must contain enough detail about the research study, the requested funding, and the Principal Investigator to enable AMS to make a final evaluation regarding support. Please see below for information regarding the submission process and requirements.

If you meet the Eligibility Requirements please:

  • Register for or Log In to the Investigator-Sponsored Research Submission Portal
  • Provide a copy of the protocol, protocol summary, or abstract for the proposed research. Required sections for a protocol summary include: Background/Rationale, Primary and Secondary Endpoints, Study Design, Inclusion/Exclusion Criteria, Target Enrollment, Informed Consent and Withdrawal, Training (if multi-center), Safety Reporting, Statistical Methods, Data Monitoring, and Publication Plan
  • Provide a budget for the proposed Research including an itemized list of what the funding is to include and any funding already received or applied for from other parties
  • Provide the curriculum vitae of the Principal Investigator. Your CV should demonstrate experience designing and managing clinical studies in accordance with applicable Good Clinical Practice guidelines and following any country and/or local approval, and safety and data privacy regulations. You will also need adequate resources including site personnel, equipment, and time necessary for the implementation of a quality study.
  • Submit your completed Investigator-Sponsored Research Application and supporting documentation via the Investigator-Sponsored Research Submission Portal

We evaluate Investigator-Sponsored Research applications against our long-term clinical evidence strategy and needs in the medical community. We prioritize funding based on alignment with the evidence strategy and the scientific soundness of the study design.

After the submission deadline, your Investigator-Sponsored Research application will be reviewed by AMS.

The review process takes between two and three months after the submission deadline depending on the volume of submissions and the funding available. The Principal Investigator will hear back from a specialist on our Investigator-Sponsored Research committee regarding the status of the application.

Important Dates

View and Print the Request for Proposals

For all Investigator-Sponsored Research studies involving human subjects, applications will be reviewed in the period following the application deadline.

2011 Application Deadline
September 2, 2011

AMS Internal Review
September—October 2011

Awards Announcement
November 1, 2011

2012 Application Deadlines
February 3, 2012
June 1, 2012
September 7, 2012

For all Investigator-Sponsored Research studies involving animal subjects, requests will be accepted throughout the year upon submission.

Review Process

AMS will acknowledge receipt of all Investigator-Sponsored Research submissions. The review process is conducted by an AMS Investigator-Sponsored Research Committee and decisions are made based upon medical and scientific merit as well as available resources and research priorities. Submission of a request does not guarantee that support will be provided. A formal notification of the status of your application will be sent once a decision is made.

Budget and Overhead

Funding for Investigator-Sponsored Research will be assessed according to fair market value. An itemized budget of expenses related to your study will be required for submission.

Direct and indirect costs may be considered in your budget submitted for review. These costs may include subject-related costs, study personnel costs directly related to the study, diagnostic fees and services, data management expenses, IRB review fees, publications costs, supply expenses, and animal-related costs if applicable. Overhead costs may be included if itemized in the proposed budget and if they are directly related to the study.

Costs not directly related to the research proposed will not be funded. These include:

  • Staffing of resources that are not dedicated to the research proposed
  • Funds establishing new clinical programs or expansion of existing programs
  • Any equipment or materials that would generate revenue for the Investigator or Institution
  • General education and training activities (See amsgiving.org for information on our Educational and Fellowship Grant Programs)